All posts by atascientific

Nanocages May Be Used to Deliver Drugs

In a new study, McGill University researchers have reported that nanoscale ‘cages’ – which are formed with strands of DNA – are capable of encapsulating drugs and releasing them when a specific stimulus is present.

This research represents an important advancement in the use of biological nanostructures for delivery of drugs to the diseased cells of patients. The results could create new possibilities for the design of DNA-based nanomaterials.

The research is important in terms of drug delivery technologies, as well as for basic structural biology and nanotechnology.

There are particular advantages for DNA structures, rather than synthetic materials, being used for the delivery of drugs within the body. DNA structures are preferable because they can be built with increased precision, they are biodegradable and it is quite easy to tune their size, shape and DNA properties.

Because they can be made to release drugs when a particular nucleic acid sequence is present, DNA cages are important.

It is understood that diseased cells (including cancer cells) overexpress particular genes. It is possible that, in the future, a DNA cube may be created that transports drug cargo to the environment of the diseased cell and release of the drug will be triggered.

Source:  http://www.sciencedaily.com/releases/2013/09/130901153347.htm

An Innovative Approach to Superlens Technology

Conventional shaped glass lenses are limited in their ability to redirect incoming light beams and have them meet at a precise point. However, a team at Singapore’s A*STAR Institute of High Performance Computing has shared an innovative approach to ‘superlens’ technology.

To develop the design, the team used numerical modelling. By concentrating radiation into a smaller volume, the interaction between light and matter is enhanced. It is expected that this concept could be useful in very sensitive sensors of the future.

As a type of wave, light consists of oscillating electric and magnetic fields. The distance travelled by a wave in one oscillation cycle is its wavelength and this involves a direct limit on the minimum size to which it is possible to focus light. However, this limit is not relevant to small distances that can be compared to the wavelength – otherwise known as the near-field regime.

The use of a ‘superlens’ (and restriction of light into intense ‘hot spots’) may prove advantageous for optical detection systems. The concept is currently targeted at biomedical and chemical sensing applications.

Source:  http://www.sciencedaily.com/releases/2013/08/130831110653.htm

Scientists Grow Model of a Human Brain

Researchers from the Institute of Molecular Biotechnology in Vienna, Austria, have used stem cells to grow a three-dimensional, self-organising model of a developing human brain.

This system could potentially be used to model neurological diseases in a real human brain, offering advantages over the use of animal models that may not develop in the same way.

The researchers refer to the model created as a ‘cerebral organoid’. It has features that mimic the early developing human brain and specific regions are present, including the dorsal cortex, the ventral forebrain and an immature retina.

To date, this is the most complex in vitro human brain tissue. Early signs of the cortical layers can be identified, although the complete six-layer human cortex and all its complexities cannot be developed.

Embryonic stem cells and induced pluripotent stem cells (derived from adult human skin or blood cells) were used to grow the organoids. Most grow to a size of three or four millimetres, which is approximately the same size as the brain of an embryonic human at 9 weeks gestation.

Juergen Knoblich, the coordinator of the study, said that despite its appearance being similar to brain tissue in the early stages of development and despite the presence of active neurons, the organoid does not replicate naturally developing tissue. He likened the project to building a car with wheels and an engine, but with the engine on the roof: the car wouldn’t be driveable, but you could still analyse how it worked.

Cerebral organoids may be used to better understand diseases such as microcephaly and, potentially, disorders such as schizophrenia and autism.

Source:  http://www.popsci.com.au/science/whoa-scientists-grow-a-brain-in-a-dish

Scientists Create New Nano-Sensors for Multiple Proteins

Scientists at the Johannes Gutenberg University Mainz (JGU) have developed a new process that allows for the rapid identification of hundreds or thousands of different proteins. The new parallel protein analysis process is fast and inexpensive, and could allow for the rapid detection and identification of viruses, even with very small samples.

Professor Carsten Sönnichsen of the Institute of Physical Chemistry says the process could be used in medicine for rapid diagnoses and is almost as easy to use as a store-bought pregnancy test. A tiny sample of saliva, blood, or bodily fluid on a test strip is inserted in the device, which then quickly identifies the different proteins in the fluid.

The device developed by Sönnichsen’s team has a sensor the size of a pinhead. The sensor can carry out hundreds of tests on a tiny surface, and the test strips feature gold nanoparticles as sensor elements. The authors of the study suggest that low-cost production is possible if advanced nanofabrication methods are used. The study is to be published in the journal Nano Letters.

Source: http://phys.org/news/2013-07-chemists-nano-sensors-multiple-proteins.html

Scientists Create Light-Controlled Gel

Researchers have made a breakthrough in mimicking the camouflage effect of some animals, such as the octopus, that change shape for survival. Scientists from the University of Pittsburgh have created a hydrogel that can be controlled by light.

Hydrogels are used in products such as contact lenses and in microfluidic or fluid-controlled technologies. The scientists were able to demonstrate that their hydrogel exhibits biomimetic behaviour and can be re-configured and controlled by light.

The study used a hydrogel created with spirobenzopyran molecules. The gels exhibited direct and sustained movement when exposed to light, and could undergo dynamic reconfiguration when exposed to different combinations of lights.

The study’s lead author Anna Balazs says that the technology could be used in different applications, particularly for functional, reconfigurable, sustainable materials. She offered the example of changing the layout and location of an apartment by simply exposing the structure to light. The study will be published in the journal Advanced Functional Materials.

Source:http://www.sciencedaily.com/releases/2013/08/130801125706.htm

Quantitative Kinematic Analysis of Jumping Crystals Presented

Crystals can jump – that’s what a team of scientists from Russia and the United Arab Emirates have discovered recently. After a systematic examination of how crystals behave in response to light, the team have presented the first quantitative kinematic analysis of jumping crystals, published in the journal Angewandte Chemie.

The crystals move thanks to a phenomenon called the ‘photosalient effect’: when irradiated by UV light, the crystals move around. The size of the crystals are micrometre or millimetre in size and of the cobalt coordination complex [Co(NH3)5(NO2)]Cl(NO3).

The effect has the crystals ‘jumping’ distances thousands of times larger than their size. According to the scientists, this happens because the irradiation process breaks the bond between the nitrite ligand (NO2) and the central cobalt ion.

As a result, the ligand ends up rotating in order to use one of its oxygen atoms to bind to the cobalt, resulting in a strain in the crystal and forcing it to jump and fracture, and sometimes explode.

The scientists used a microscope-mounted high-speed camera to capture the phenomenon. They observed that the distance covered by the crystal’s movement depends on how long it is exposed to irradiation and how intense the light is.

They also found that there is a lag stage between exposure and movement, as the stress caused by the irradiation builds up. The findings could be useful for the design of materials and technical components.

Source: http://phys.org/news/2013-07-crystals-kinematic-analysis-light-induced.html

Protein Powering Insects’ Jumps Inspire Medical Application

A special rubber-like protein that enables insects to jump, flap their wings, and chirp could have wide applications in medical science, according to research published in ACS Macro Letters.

While scientists discovered resilin half a century ago, it is only in recent years that scientists have begun to look at the potential medical and scientific applications of the protein.

Resilin is found in the wing hinges of locusts and tendons of dragonflies. Scientist Kristi Kiick says that the natural protein is unmatched by even the best synthetic rubbers that are currently available. Resilin can be stretched to three times its original dimensions and still spring back to its original shape without any loss of elasticity, even when stretched and relaxed many times.

Scientists have already created resilin-based products that could be used in diagnostics, cartilage replacement, cardiovascular applications, and traditional polymer applications. Resilin products could be used in nanosprings, biosensors, and biorubbers in the future.

Source: http://phys.org/news/2013-07-insect-inspired-super-rubber-medicine.html

New Game-Changing Approach for Synthesizing Compounds

A team of eight scientists led by David C. Johnson of the University of Oregon has invented a new technique for rapidly synthesizing compounds with very low thermal conductivity and other unique properties.  The new method is a major breakthrough, as the traditional method is more time-consuming and limited in its application to only a few compounds that are thermodynamically stable.

The technique involves lightly warming a design of layered elemental precursors. Having been exposed to warmer temperatures, these automatically assemble into 18 new metastable and nano-sized compounds.

The new technique is revolutionary and has been described as paradigm changing. The traditional method for synthesising crystalline materials (in solid-state inorganic chemistry) has been limited in scope and application. This was largely due to the time and amount of heating required.

As Johnson states, it is now possible to make 20,000 compounds rather than only three. Johnson adds that the technique is possible because his team has found a way to control local compositions and diffusion distances of precursors.

Kimberly Andres Espy, the University of Oregon’s vice president of research and innovation, says that the new approach developed by Johnson and his team could potentially help create a more sustainable future for the world. This is because the technique has the potential to change how critical products are manufactured and delivered.

Source: http://phys.org/news/2013-07-team-game-materials.html

Flexible Plastic Skin Could Be Used on Touch-Sensitive Robots

A team of scientists of the University of California Berkeley has created a flexible plastic skin that could be used to make touch-sensitive robots. The electronic skin, dubbed ‘e-skin’ has an inbuilt sensor network that lights up when touched. The stronger the pressure, the brighter the light.

Ali Javey, Associate Professor at the university and leader of the research team, says that the e-skin can be wrapped around different objects. Javey adds that it is a system rather than a device. The device has a broader application than robotics; it could be used for wallpapers that also function as touchscreen displays, controllable dashboards in cars, and bandages as health monitors, says the study’s co-lead author Chuan Wang.

The e-skin is made from polymer, silicon, and electronic components. Javey says the technology will be easy and relatively inexpensive to commercialise.

Wang says it is the interactivity of the e-skin sensor system that makes it something new as an invention. The flexibility of the skin means it can be applied to many different surfaces. The team is now focusing their efforts on making the e-skin responsive to temperature and light.

Source: http://www.sciencedaily.com/releases/2013/07/130721161716.htm

Efficient Production Process for Nanocrystalline CeO2

Scientists from the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) and the University of New South Wales have discovered a formation mechanism of nanocrystalline CeO2 particles.

The findings will have a fundamental impact on current methods for producing CeO2 nanocrystals and is likely to simplify the production methods that are currently available. The scientists used a multi-spectroscopic technique to observe the nanocrystal evolution process.

Current methods of synthesising nanocrystalline CeO2 particles are based on sol-gel and thermal treatments or by adding accelerant reagents. The new study has enabled a better understanding of how the metal nanocrystal particles are formed at the atomic scale, in an aqueous solution.

The study found that it is possible to produce uniformly sized nanoparticles of CeO2 in a size suitable for industrial application. The technique involves pH adjustment of tetravalent cerium in an aqueous solution, in the absence of any chemical or heat treatment afterwards.

Dr Christoph Hennig, one of the scientists involved in the study, said that the multi-spectroscopic technique is applicable to other types of research on metal nanocrystals. Nanocrystalline CeO2 particles are used in a variety of industrial and medical applications.

Source: http://www.sciencedaily.com/releases/2013/06/130625121155.htm