All posts by atascientific

Applying Powder Rheology to Optimise Industrial Powder Handling Processes

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Powders are extensively utilised across a wide range of industrial process and applications but they continue to present significant challenges in terms of storage, processing and QC. This presentation discusses those challenges and introduces powder rheometry as a method for assessing powder behaviour. Real-world cases studies using the FT4 Powder Rheometer® are presented to illustrate the industrial value of the technique.
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Powder Flow Testing with the FT4 Powder Rheometer The FT4 is a truly universal powder flow tester, with four categories of methodologies, defined as Bulk, Dynamic Flow, Shear (in accordance with ASTM D7981) and Process.

   

Turbocharge your biologics discovery and development, while simplifying your workflow

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ATA Scientific is pleased to announce Malvern Panalytical’s Creoptix WAVEcore!!!

Creoptix WAVEsystem – Kinetics in hours instead of days

Conventional bioassays like Surface Plasmon Resonance (SPR) have relied on enzyme or fluorescent labels to detect and monitor biomolecular interactions, but these methods tend to capture just one point in time and are fraught with non-specific binding issues that can skew results. 

Malvern Panalytical’s Creoptix® WAVEsystem, is a label-free technology that delivers highly sensitive kinetic and affinity results (ka, kd, KD) in real-time in a wide range of biological matrices that’s simply not possible with conventional methods. High-quality data can be derived from even the most challenging sample types with superior resolution to deliver deeper insight into previously undetectable interactions.

Built around the patented Grating-Coupled Interferometry (GCI) technology, the Creoptix WAVEsystem’s design leverages and enhances the intrinsic benefits of Waveguide Interferometry to enable faster kinetic characterisation. 


BENEFITS:  Save time and costs: more interactions in hours, not days
Get more insight: capacity to screen broad kinetic range 
Run more samples: transform 96 well plate to 96 datasets  
Ease-of-use: Up to 120 hours of unattended operation
No-clog: crude samples, harsh chemicals, and particles up to 1000 nm
Superior signal-to-noise ratios (0.01 pg/mm2 at 1 Hz)
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Download Free Kinetics Guide

Introducing waveRAPID from Creoptix, the new way of measuring kinetics to boost throughput. Take a look at this short video comparing the sensitivity of Surface Plasmon Resonance (SPR) technology and Grating-Coupled Interferometry (GCI) technology.    

Webinar: Advancing drug deformulation with advanced analytical characterisation tools

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Recent breakthroughs with mRNA-based vaccines highlight the potential of lipid-based particles as powerful and versatile delivery vectors for vaccines and gene therapies. Used to measure particle size, stability, zeta potential and particle concentration, light scattering techniques are used extensively in the characterisation of lipid nanoparticle and liposome research.

The Zetasizer range of light scattering instruments provides high quality, stability-indicating data for drug molecules and their formulations. Delivering data in a short time frame, the Zetasizer allows you to implement this technique throughout the development pipeline.

This webinar explores the challenges and opportunities drug and vaccine developers are currently facing and explains how the Zetasizer can be used to address these and to optimise your formulations. Learn how and why size, zeta potential and particle concentration can be used as critical quality attributes in lipid nanoparticle and liposome formulations Explore how DLS can be used to optimize lipid-based formulations and process conditions, such as monitoring stability, understanding surface modification, and developing formulations Understand the significance of Non-invasive backscatter (NIBS) optics for reliable measurements of concentrated, turbid samples without the need for dilution
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CREOPTIX WAVE

New products

The Creoptix® WAVE system enables high-sensitivity, label-free analysis of binding kinetics and affinity analysis for drug discovery.

Conventional bioassays, like Surface Plasmon Resonance (SPR) have relied on enzyme or fluorescent labels to detect and monitor biomolecular interactions, but these methods tend to capture just one point in time and are fraught with non-specific binding issues that can skew results.

Malvern Panalytical’s Creoptix® WAVEsystem, is a label-free technology that delivers deeper insight into previously undetectable interactions. Kinetic rate parameters and affinity constants (ka, kd, KD) along with binding specificity are derived in real-time from even the most challenging sample types in a wide range of biological matrices.

The power behind the Creoptix WAVEsystem is in the patented Grating-Coupled Interferometry (GCI) technology and non-clog WAVEchip microfluidics system. GCI is unique and measures the evanescent wave across the entire sensor surface and isn’t affected by temperature drifts or vibrations, allowing for more sensitive measurement.  The kinetics of weakly binding fragments and large molecules with high affinity and slow dissociation can be measured simply (even native proteins in complex matrices) without purification. The waveRAPID method can also be used to increase throughput, particularly in screening applications, by generating a pulsating concentration profile. Calibration-Free Concentration Analysis (CFCA) offers a reliable, quick and easy calibration-free approach to quantify active protein concentration.

For further details contact us

Ready to Watch Webinars focused on particle characterisation: Tips and tricks

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These webinars are designed for you to sharpen your analytical methods, deepen your knowledge, or find out how to improve your data. They provide extensive materials analysis information and answer incoming questions on each topic.

Each webinar covers an aspect of sample preparation, data collection or analysis and reporting. These events are all free to join, and you can attend as many as you like to support your research or build your knowledge. The list below has information about the topics we will discuss at each event, with links to register for upcoming sessions. 

Why not sign up for Malvern Panalytical event notifications? You will be notified a month in advance of each event to make sure you don’t miss out!
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ITC for organic solvents: Tips for success with this trending application in Chemistry and Life Sciences

How well can you present your DLS results?
 
Dive deeper into multi-detection OMNISEC Software

Key takeaways for error-free analysis and reporting laser diffraction results
 
Ensuring sample integrity during zeta potential measurements

Register now: October 20, 2022 
Microcalorimetry: a versatile biophysical tool to understand biomolecular interactions    

Learn more – Take a look at the Vector Analytics Masterclass Series below  
Understand the strengths and weaknesses of key characterisation techniques used to characterise the physical and chemical attributes of lipid nanoparticles (LNP) encapsulating mRNA including: dynamic light scattering (DLS); multiangle-DLS (MADLS); electrophoretic light scattering (ELS); nanoparticle tracking analysis (NTA); multiple detection SEC; differential scanning calorimetry (DSC).

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Create thin film coatings with controlled packing density – KSV NIMA User Day online

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6th October 2022 
In 1932 Irving Langmuir was awarded the Nobel Prize in Chemistry “for his discoveries and investigations in surface chemistry”. Still, 90 years later, researchers around the world utilise the theories Langmuir develop to make new discoveries.

Commemorating the 90 years of Langmuir Nobel Prize, Biolin Scientific brings the community together by hosting KSV NIMA User Day online. 

Two sessions will be held (morning and afternoon) with 8 invited guests speakers and basic training in Langmuir & Langmuir Blodgett.

Sign up today to be part of an exciting day!
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Meet the new ISR Flip. The most sensitive and versatile interfacial shear rheometer yet.    

Online demo of the QSense Pro QCM-D instrument

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21st September 2022 at 4pm
QSense® QCM-D enables studies of molecule-surface interactions. With nanogram precision, you can follow events at the surface as they happen, and quantify mass, thickness, and structural properties. You can use it to study adsorption/desorption, binding/release, conformational changes, and much more. QSense Pro is your go-to instrument when you want high level of automation, increase the throughput, test and compare samples, high reproducible results, conduct experiments in both high and low temperatures. Join us for an online demo of QSense Pro to; Get a quick tour of the instrument An overview of the QSoft pro 401 Software See the instrument in action with an experiment Clarify your questions with our experts The session is hosted live by one of our experts with a pre-recorded demo to give you the best possible experience. You will be given the chance to ask questions during the Q&A Session.
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Widen your view.
This 3-minute video will give you a quick view of QSense Pro measurements and applications.    

Generate high-resolution images in less than a minute using Phenom Desktop SEM

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Since the introduction of electron microscopes in the 1930s, SEMs have evolved into a critical tool, spanning everything from materials science, to forensics, to industrial manufacturing, and even to the life sciences. Now the desktop Phenom SEMs  redefine ease of use, speed and performance making them accessible to everyone.  

Desktop SEM with automated QC  

Take a look at the new on the Thermo Scientific Phenom XL G2
Product Development Engineer Luigi Raspolini explains how this versatile desktop SEM automates quality control, from sample loading and automated workflows through to imaging and analysis. Now even easier thanks to the new user interface – Free up more time, to add more value.   
The Phenom XL is specifically designed for automated analysis of large or multiple samples in the same load cycle. Equipped with a long lifetime and high-brightness CeB6 source, it enables excellent imaging of samples up to 100 x 100 millimeters.  

Desktop SEM reveals the finest detail   

The award-winning Phenom Pharos is the first desktop SEM on the market to include a field emission gun (FEG), which allows very high-resolution images. As with all Phenom models, the Phenom Pharos is easy to operate and incorporates fast time-to-image and easy handling. The Phenom Pharos makes the benefits of a FEG source accessible to everyone.    
Desktop SEM for routine SEM analysis

The Phenom ProX provides high performance and very fast results for routine SEM imaging and analysis. It includes a fully integrated EDX detector that allows elemental analysis. The current generation-5 version offers excellent resolution and support a wide range of applications, including samples sensitive to charging and beam damage.  
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Phenom ParticleX Steel Desktop SEM measures the size, morphology, and chemistry of inclusions (typically where failures occur) to help optimise manufacturing while accurately certifying the quality of steel products.  


Watch our on-demand webinar to learn more about Steel-specific software and automation designed specifically for inclusion analysis in metallurgic samples.
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Phenom™ ParticleX Steel Desktop SEM provides fast, accurate and complete information steel makers need to optimise their production process.
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Characterising Amyloid-Forming Immunoglobulin G Light and Variable Chains Using Microfluidic Modulation Spectroscopy (MMS)

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Protein structure is vitally important to function, however, loss in activity is not the only misfortune for misfolded proteins as they can also be immunogenic and disease-causing as in the case of amyloid plaques. Light chain amyloidosis results from the aggregation of the light chain in Immunoglobulin G (IgG) which is one of the most prevalent proteins in human serum.

In this webinar, we will cover the structural analysis of both light and variable chain domains of non-disease-causing IgGs from germline (GL), potential disease-causing domains from patients with multiple myeloma (MM), and disease-causing domains from amyloidosis patients (AL). Each sample was analyzed using Microfluidic Modulation Spectroscopy (MMS), a high-precision secondary structure characterization tool developed by RedShiftBio. Full structural characterization of IgG is important because the mechanism of aggregation is still unknown and further elucidation could lead to insights into potential treatments and cures.
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 RedShiftBio’s structural analysis instrument, the AQS³pro and Apollo, provides users with the ability to measure critical changes in bimolecular structure.  AQS³pro overcomes many of the limitations of traditional spectroscopy-based technologies, with ultrasensitive, highly reproducible, automated structural measurements of proteins and other biomolecules.
 
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