All posts by atascientific

Webinar: Advancing drug deformulation with advanced analytical characterisation tools

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Wed, 14 September 2022 
Live Webinar: Smart application of analytics in complex generic drug development

Specialised analytical techniques like chromatography, spectroscopy, morphology, and bulk material characterisation are important for deformulation analysis and to validate performance ‘sameness’ of generics to the innovator drug. If you are working with complex generics such as peptide based injectables, liposome-based drugs or OINDPs, join us in this webinar to learn more about smart implementation of analytical characterisation tools within the generic drug development process to meet Q2/3 regulatory requirements.
 
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Your Solution to Protein Characterisation Has Landed

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Join Our Workshop, Register Today!  
ATA Scientific would like to invite you to attend our free workshop and use the new RedShift Bio AQS3Pro – the first system to arrive in Australia!
Measure protein stability, structure, similarity and aggregation all from a single automated run.
The AQS3Pro uses Microfluidic Modulation Spectroscopy (MMS), a novel fully automated technique providing ultra-sensitive, ultra-precise structural measurements of proteins and biomolecules. The system is able to detect <2% change in secondary structure in a wide range of sample concentrations (<0.1 mg/ml to >200 mg/ml). It’s easy to use and fully automated with both 24 and 96 well plates.

Join us and test drive the AQS3Pro
   
This workshop will provide you with further insights and show the benefits of incorporating MMS into your suite of tools for protein characterisation. Stability, structure, similarity, and intermolecular aggregation will be measured from a single automated run. A brief outline of the technology will be discussed followed by a demonstration and “hands on” time for sample analysis. You are welcome to bring your own samples for analysis.

Contact us today to book your free workshop today!  

Location: ATA Scientific lab, 47 Cawarra Road, Caringbah, NSW 2229 MAP

Registration: Please register your interest to use the AQS3Pro by completing the registration form online or email us with your details.  We look forward to seeing you at our workshop.
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Advancing Structural Characterization of Therapeutic Proteins Using MMS

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Existing tools for measuring and monitoring the structure of biotherapeutic molecules during formulation have, until now, had very significant limitations in sensitivity and ease of use. 

In this webinar, we share data that demonstrates the power of Microfluidic Modulation Spectroscopy (MMS), a valuable, fully-automated IR technology, to generate high-quality, reproducible secondary structure data for protein therapeutics, including monoclonal antibodies. 

Learning Objectives: 
•    How Amgen obtained high-quality structural data on low concentration mAbs to enable more confident decision-making in the formulation process
•    How to detect previously undetectable structural changes in therapeutic proteins to profoundly affect quality control outcomes using MMS 
•    The fundamentals of Microfluidic Modulation Spectroscopy and advantages over existing techniques

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RedShiftBio’s structural analysis instrument, the AQS³pro and Apollo, provides users with the ability to measure critical changes in bimolecular structure.  AQS³pro overcomes many of the limitations of traditional spectroscopy-based technologies, with ultrasensitive, highly reproducible, automated structural measurements of proteins and other biomolecules.    

Measuring Buffer-Induced Structural Changes in a Beta-sheet Rich Protein using MMS
 
In this study, the structural differences of alpha-chymotrpysin, a beta-sheet rich protein, were characterized in water and three common formulation buffers using MMS. Alphachymotrypsin was prepared in HPLC-grade water as a reference, as well as in Phosphate Buffer (PB), Phosphate Buffered Saline (PBS), and Tris buffer. Absorption spectra in the Amide I region were automatically collected and processed to monitor critical structural components including the beta-sheet content, HOS motif percentages, and to calculate the overall structural similarities between samples in all prepared conditions. The resulting analysis and comparison across all buffer conditions show that alpha-chymotrypsin undergoes buffer-induced structural changes.
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NEW partnership with InProcess LSP

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PRESS RELEASE: Unique Nanoparticle Analysing Technology from InProcess-LSP launched in Australia by ATA Scientific Pty Ltd

InProcess-LSP and ATA Scientific Pty Ltd are pleased to announce they have entered into a partnership, combining ATA’s Analytical Instrument expertise in Australia and New Zealand with InProcess’s world class and groundbreaking nanoparticle sizing technology delivering unique solutions for the particle characterisation markets.   

ATA Scientific is an analytical instrument provider for Australia and New Zealand. Established over 30 years ago they have built an extensive customer base throughout Australia and New Zealand. This includes Universities, CSIRO and a diverse range of companies in the pharmaceutical, polymer, chemical and mining industries.

With nanoparticle sizing technology playing an increasingly critical role in every aspect of R&D, scale up and manufacturing of complex nanosuspensions, companies recognize that they need to adopt the next generation technology to ensure they remain on the competitive vanguard. The ATA – InProcess-LSP partnership brings together market and technology expertise for nanoparticle characterization to help support clients through successful transformations such as adaptation of Process Analytical Technology. With this agreement ATA Scientific can add the NanoFlowSizer as a solution for nanoparticle characterization in their offerings.

“The NanoFlowSizer will allow ATA Scientific to target in-process monitoring applications. The combined efforts of ATA’s applications expertise   and InProcess- LSP’s NanoFlowSizer technology will add great opportunities in the various markets we serve”

                                              Bryn McDonagh, General Manager, ATA Scientific

InProcess-LSP is an innovative organisation providing groundbreaking analytical services and solutions to support process analytical challenges. Being experts in nanoparticle size characterization, they are the inventors of the NanoFlowSizer:  a unique, non-invasive nanoparticle size instrumentation for real-time measurement.

Partnering with ATA Scientific to deliver first class support  for various clients in pharmaceutical, Food & Dairy, mining, chemicals and coatings markets will allow us to continue our focus on developing the technology further for their needs” 

Frando van der Pas, Director of Sales  InProcess-LSP

 “Utilising their extensive sales and marketing expertise, we are confident that with our combined efforts and by working together closely, ATA Scientific will support the growth we have anticipated in these markets” he added.

About InProcess-LSP

InProcess-LSP founded in 2014. The InProcess-LSP team has a great experience and interest in  PAT  science and a strong background in process and product development. Our analytical capabilities include low-coherence interferometry; UV/VIS, NIR and Raman Spectroscopy, high-resolution microscopes and NIR Imaging. In 2019 InProcess-LSP commercialized the first and unique NanoFlowSizer technology. The NanoFlowSizer is a new innovative system for continuous, real-time nanoparticle size characterization of colloidal systems, nanosuspensions, nanoemulsions and other dispersed nanoproducts directly in manufacturing processes (inline) or in a laboratory setting (offline). For further information please visit https://www.inprocess-lsp.com   

About ATA Scientific

ATA Scientific specialises in marketing and servicing analytical and scientific instruments. We represent a group of international companies who are all highly regarded in their fields. Their innovative instruments are applicable across the Particle, Surface, Life and Material Sciences. Applications range from routine QC to advanced nano and biotechnology research.

We operate throughout Australia and New Zealand. Over the past 30 years we have built an extensive customer base. This includes Universities, CSIRO and a diverse range of companies in the pharmaceutical, polymer, chemical and mining industries.

The essence of what we do is to provide the instruments and know-how for you to obtain meaningful and reliable analytical results. We do this by listening to your requirements and taking care to supply the most suitable technology together with on-going help. For further information please visit  https://www.atascientific.com.au/

Micromeritics Autochem III

New products

All NEW AutoChem III is a catalyst characterisation laboratory in a single instrument. This highly automated and highly accurate system is ideal for chemisorption and temperature-programmed reactions. The new design saves time, makes the most sensitive, reproducible measurement and enhances operator safety.

The NEW AutoCool is an integrated gas-fed system that rapidly cools sample tubes before and during experiments. AutoCool is typically 30 minutes faster than alternative systems and requires no liquids or external support.

The NEW AutoTrap removes moisture without cryogenic liquids such as liquid Nitrogen. It effectively traps vapour and requires no manual slush bath preparation. Traditional methods for vapour capture require the time-intensive process of slush-bath preparation through the manual mixing of liquid nitrogen with isopropanol. The zeolite bed of the AutoTrap effectively captures vapours, can be used for several experiments without interruption, and can be regenerated in situ.

Automated detector calibration makes accuracy simple by using patented gas blending and a dedicated reference stream flow controller. Patented new KwikConnect fittings make sample tube installation faster, easier, more reliable and reduces the risk of breaking sample tubes. With 18 available gas streams, users are always ready to run their next reaction.

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LUXOR auto metal coating solutions

New products

LUXOR fully automated metal coating systems apply a fine grain platinum or gold coating from 1 to 100 nm thickness for improved SEM analysis. Metal coatings strongly reduce sample charging by increasing conduction allowing detectors to pick up more hi-res imaging details. The unique ‘upside down’ design of the LUXOR Pt makes sure that loose particles will be removed during the coating process which helps to protect the SEM from contamination and damage.
Benefits: 

  • COMPLETELY AUTOMATED
  • UNIQUE A² TECHNOLOGY
  • UPSIDE DOWN DESIGN
  • TRIPLE FUNCTIONALITY
  • ROBUST DESIGN, MADE IN GERMANY

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‍Introducing Apollo, the automated, high sensitivity, protein structural characterisation tool

New products

Apollo provides ultra-sensitive, ultra-precise measurements of the structure of biomolecules through a novel technology called Microfluidic Modulation Spectroscopy (MMS), now even more rapidly, with less sample volume, and with improved software and analytics features.  

MMS overcomes many of the limitations of existing technologies in a typical biophysical characterisation toolkit with ultra-sensitive and highly reproducible structural measurements of proteins and other biomolecules. Users are able to compare higher-order structure and similarity profiles for confidence in structural similarity and activity to inform discovery, screening, formulation, and quality control in biopharmaceutical drug development. It can be used for a wide range of biomolecules from mAb-based biotherapeutics to robust measurements of ADCs, AAVs, and mRNA.

Key features and benefits of Apollo include:  

  • Accurate and reproducible measurements with broad concentration range from 0.1 mg/ml to >200 mg/ml allows measurements in native conditions
  • 20x faster and 30x more sensitive to changes in structure than CD or FTIR
  • Real-time buffer subtraction minimises background noise and interference from excipients

Dramatically reduced sample volume requirements 

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Phenom XL G2 for SEM imaging and analysis within an argon filled glove box

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Perform both preparation and analysis of air-sensitive battery materials in the same workspace.
With the Phenom XL G2 Argon-Compatible Desktop SEM, you can now perform solid-state lithium battery research in a non-reactive argon environment. The Phenom XL G2 Argon-Compatible Desktop SEM can be placed in an argon glove box, allowing sample preparation and SEM/EDX analysis for element identification within the same workspace. This setup enables research on solid-state lithium batteries since it decreases the risk of sample degradation due to lithium oxidation. By eliminating the need to move the research sample from one instrument to another, you can retain sample integrity and save time and resources.
READ MORE HERE

 
ATA Scientific is a proud sponsor of the 21st international meeting on lithium batteries (IMLB2022), to be hosted at the ICC, Sydney. Join us at our booth together with our partners (MalvernPanalytical and ThermoFisher Scientific) and discover how we can help you ensure the quality of your incoming battery materials, cell performance and cycle life.
 
3D imaging of Lithium-ion batteries
A detailed understanding how the 3D structure impacts the performance, and how this structure changes upon cycling, is needed to optimize current battery designs and to develop next-generation battery materials. Find out more.
WATCH WEBINAR NOW
 
Automate your quality control
If you have an SEM workflow with repetitive tasks to analyse particles, pores, fibers, or large SEM images, you can allow the Phenom XL G2 Desktop SEM to do this for you automatically using Python Scripting (PPI). Find out how.
REGISTER & WATCH WEBINAR NOW  
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Resolve additive manufacturing quality control issues with both particle size & shape analysis

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WEBINAR: 23 June 2022 @ 4pm (Sydney) 
Additive manufacturing (AM) is cited as one of the most disruptive technologies of 21st century, as it can be used to produce highly complex parts while reducing waste when compared to traditional subtractive methods. Properties such as particle size, particle shape, and particle morphology of raw materials are crucial  as they affect the packing behaviour and flow characteristics of the powders which can significantly impact the quality of the final product.

This webinar will outline how laser diffraction (Mastersizer 3000) together with imaging ( Hydro Insight & Morphologi 4) offer a highly effective method for assessing the overall quality of the raw materials used in AM. We will also look at powder recycling in powder bed fusion AM processes and how to achieve the required ISO norms and adhere to the ASTM standards for feedstock analysis. 
Can’t attend live? Register anyway to receive a recording. 
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Mind the gaps – safe steps to qualifying AM processes and products
This talk will cover the development of AM standards and how these can be utilised to support qualification and certification.

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Shape up: Learn why particle shape and size are critical for Additive Layer Manufacturing
This webinar looks at the relevance of particle size and shape to the AM process and how to measure them.

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Explore 3D printing materials science with Professor Rigoberto Advincula
Delve deeper into AM and specific polymeric applications, and touch on how the field overlaps with the use of gel permeation chromatography for polymer characterisation. 

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Check for microstructural defects in additive manufacturing using X-ray diffraction
In this webinar, Dr. Olga Narygina will discuss the importance of XRD for metal additive manufacturing, including powder and component analysis. 
WATCH NOW  
  WANT MORE?  For a full overview of the 2022 webinar program, click here.  To watch any of last year’s webinars, take a look at the full program recordings here.
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Develop fast-charging and stable Lithium batteries using EQCM-D

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The development of a solid electrolyte interface (SEI) is an important parameter that decreases the performance and lifetime of lithium battery. A solid layer builds inside the lithium battery as we start using it. The formation of this solid layer blocks the passage between the electrolyte and electrodes heavily affecting the performance of the battery.

Gain insights through time-resolved nanoscale analysis using Electrochemical Quartz Crystal Microbalance with Dissipation Monitoring

Battery technology is constantly developing and new generations of electrolyte, anode and cathode materials are being developed. EQCM-D has been used particularly for battery materials that undergo changes in viscoelastic properties. 

If you would like to arrange a demonstration to assess the capabilities of this technology, please contact us.
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ATA Scientific is a proud sponsor of the 21st international meeting on lithium batteries (IMLB2022), to be hosted at the ICC, Sydney. Join us at our booth together with our partners (MalvernPanalytical and ThermoFisher Scientific) and discover how we can help you ensure the quality of your incoming battery materials, cell performance and cycle life.
  EXAMPLES OF RECENT PUBLICATIONS WHERE QSENSE EQCM-D IS USED TO ANALYZE SEI
CLICK HERE

Calendering is a common compaction process for Li-ion battery electrodes that enhances the energy density, however affects surface structure. Measuring surface roughness and contact angle can give more insight into the wettability of the surface.
 
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Listen to the full interview with Prof. Berg to learn more about batteries, how they work, and how the Li-ion battery research was initiated and finally resulted in a Nobel prize award.

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Batteries, supercapacitors and fuel cells – What is the difference? Here we will take a closer look at how they work and how and where they are typically used.

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Learn more about energy storage via podcast, Science on surfaces – a bigger perspective on the small. Find out different ways to store energy, challenges and limitations, and what the future looks like.
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