All posts by atascientific

Expand your capabilities with reliable particle size analysis

Newsletters
The COVID-19 pandemic has posed significant challenges for supply chains globally. So, it is with some reassurance that some things remain consistent, such as the use of laser diffraction to measure particle size distribution to control quality of powders and suspensions. 

Mastersizer leads the market for reliable particle size analysis for industries like cement manufacture, food formulation, and pharmaceutical development. So why is the Mastersizer 3000 so readily trusted by so many people? And what makes laser diffraction particle size analysis the centerpiece of thousands of laboratories across the world? Join leading experts to discover why people choose Malvern Mastersizer for their particle analysis needs.

WATCH WEBINAR NOW    
This webinar series returns to the fundamentals of laser diffraction and will help you get a firm hold on best practice, method development and applications. Register below to watch live or receive a link to the recording.   The art and practice of method transfer

REGISTER NOW    24 NOV 2021
Mastersizer 2000 reaches the end of its supported life in April 2022. If you are a user, you need to act now to plan your upgrade and safeguard your method transfer activities. This is a great opportunity to verify approved methods for Mastersizer 2000 and plan its transfer to the Mastersizer 3000. 

Best practice for the development of particle size analysis methods
REGISTER NOW     30 NOV 2021
Investigate the process of optimising both wet and dry dispersion methods and validating these methods, or alternatively ensuring that methods are successfully transferred between instruments, platforms or locations.   
Back to basics: Particle size analysis for pharmaceutical development and manufacture
WATCH NOW   
Learn how particle size analysis is applied in the pharma industry; Understand the regulatory guidance relating to particle size analysis; Understand how specifications may be set for particle size analysis
Everything pharmaceutical scientists need to know about solid form characterisation 
WATCH NOW
This three-part webinar series, uses real-life case studies to show the analytical techniques that make active pharmaceutical ingredient (API) candidate selection process more productive.
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MEASURE SECONDARY STRUCTURE WHERE OTHERS CAN’T WITH AQS3PRO

Newsletters
Understand Protein Behaviour, Conformational Stability, and Aggregation Pathways
Microfluidic Modulation Spectroscopy (MMS) is a powerful new IR-based analytical technique that provides direct measurement of previously undetectable changes in protein structure.

MMS overcomes many of the limitations of traditional spectroscopy-based technologies (e.g. FTIR & CD) with ultrasensitive, highly reproducible, automated structural measurements of proteins and other biomolecules. It can be used for a wide range of applications from formulation development of mAb-based biotherapeutics to robust measurements of ADCs, AAVs, and mRNA.

Key benefits of the AQS3pro:
Ability to measure wide range of native sample concentrations from <0.1 mg/ml to >200 mg/ml Fully automated sample-handling, with both 24 and 96 well plate formats Real-time background subtraction eliminates need to dialyse samples, no labels required Detection of <2% change in secondary structure even at low concentrations Advanced onboard data analytics enabling rapid and robust data interpretation and reporting
  CONTACT US FOR A DEMO TODAY  
What is Microfluidic Modulation Spectroscopy (MMS)? 
 
WATCH THIS SHORT INTRO
This short video introduces the AQS3pro – A Microfluidic Modulation Spectroscopy Platform for Protein Characterisation. The AQS3™pro measures protein and peptide structure, using Microfluidic Modulation Spectroscopy (MMS).

GET YOUR FREE E-BOOK
This eBook introduces you to MMS which provides direct measurement of previously undetectable changes in protein structure. Measure aggregation, quantitation, stability, structure, and similarity within a single sample or between samples. using an automated platform. 
   
AQS3Pro Powered by Microfluidic Modulation Spectroscopy
MMS is a unique, patented technology in which the sample (protein) solution and a matching buffer reference stream are automatically introduced into a microfluidic flow cell. The two fluids are rapidly modulated (e.g. 1-5 Hz) across the laser beam path to automatically perform background subtraction, dramatically improving measurement precision, accuracy, and signal-to-noise.     DOWNLOAD A COPY OF THE BROCHURE    

Discover how MMS can strengthen your bioanalytical tool kit by providing critical insight through all phases of protein-based drug development. Watch the latest recorded webinars now!
 

WATCH THIS WEBINAR

Dr. Lucy Liu of Pfizer demonstrates MM-IR secondary structure analysis of therapeutic monoclonal antibodies (mAb) and shows higher sensitivity and repeatability for low concentration samples over FTIR.   
WATCH THIS WEBINAR

Dr. Shawn Owen discusses advanced characterisation techniques including MMS to assess biophysical properties of antibody-drug conjugates (ADCs).   
CONTACT US FOR MORE INFORMATION  

In-Solution Affinity Measurement of a Drug-Induced Protein Complex

Newsletters
Decades of research have led to a remarkable understanding of protein structure and function. However, proteins rarely act on their own and a quantitative understanding of their interaction mechanisms is key to the successful development of new drugs that enable the modulation of the cellular network of protein–protein interactions.  
 
In the study presented here we have quantified the effect of rapamycin, a small molecule immunosuppression drug, on the protein complex formation of FKBP12 and mTOR using an in-solution assay that enables the characterization of otherwise challenging multi-protein complexes under close to native conditions.  
SEE THE FULL STUDY HERE

This collection of must-watch webinars cover a range of topics from measuring antibody affinity in serum to monitoring of SMALP nanodisc formation, to quantifying the stoichiometry and binding affinity of protein–protein interactions in complex backgrounds.  All webinars are available to view on demand  


Immune responses to SARS-CoV-2
In this webinar, Professor Akiko Iwasaki will discuss immune responses in COVID-19 patients with moderate and severe disease. She will compare viral load, immune phenotype and cytokines that are predictive of mortality, and discuss signatures of cytokines and growth factors that associate with recovery vs. disease exacerbation.

Safe, Rapid and Variant-Specific Affinity-Based Virus-Neutralization Assays
A new type of rapid assay is discussed based on quantifying protein interactions and provides functional insights equivalent to the gold standard cell-based neutralization assay by measuring the affinity, concentration, and neutralization potential of antibodies against the SARS-CoV-2 spike protein directly in serum. 
 
CONTACT US FOR MORE INFORMATION  

Take a closer look: Fluidity One-W Serum highlights
* Uses microfluidic diffusional sizing (MDS) technology to measure changes in molecular size (hydrodynamic radius) as binding events occur
* Enables development of customized protocols to study a wide range of interactions – typical run time 8-14 minutes per datapoint
* Eliminates risk of binding artefacts or other surface constraints – measure directly in solution – no surface immobilization
* Minimizes consumption of precious samples – 5 μL per datapoint, 60-100 μL to determine KD
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Select the Scanning Electron Microscope that meets your needs

Newsletters
It is a good time to be in the market for a scanning electron microscope (SEM) but where do you start? For researchers in academia or industrial R&D, it is important to match the SEM capabilities to the needs of the lab and its users. This webinar explains how different applications translate to requirements for different features and specifications on the SEM. 

In this webinar, we discuss what performance you can expect from a tungsten / FEG / in-lens FEG / UC FEG and how to deal with different types of samples (insulators, nanomaterials, sensitive materials).   

WATCH ON DEMAND    

Particle Analysis Applications using a Desktop SEM
Phenom ParticleX Desktop SEM (Scanning Electron Microscope) is a multi-purpose desktop SEM designed for multiple applications such as Additive manufacturing, Technical cleanliness, Steel manufacturing, Batteries/ energy storage and Gunshot residue analysis.
Beginning October 27, 2021, this six part series will focus on one particular analysis application and how the Phenom ParticleX Desktop SEM overcomes some of the most common challenges. Webinars will be made available to you for on-demand viewing shortly after the live sessions occur. 
REGISTER NOW  

CALL US FOR A PERSONAL DEMONSTRATION
Bookings are available now. Should you wish to use a desktop SEM or need further information,  please contact our specialist team via email, enquiries@atascientific.com.au, or call us directly 02 9541 3500.  

Take a closer look: Book your Phenom Pharos SEM demo
The NEW Phenom Pharos G2 Desktop Field Emission Gun – Scanning Electron Microscope (FEG-SEM) has arrived and is ready for use at our office in Sydney. We invite you to send us your samples today! Limited time only.

Phenom Pharos G2 combines all the capabilities of a floor-standing FEG-SEM in a tabletop system with the simplicity that Phenom desktop SEMs are known for. Fully integrated advanced detectors acquire high-quality images up to 2 million times in magnification, at 2.0 nm resolution and up to 20 kV. Users can also image soft, beam-sensitive or insulating samples at energy levels as low as 1 kV, obtaining high-resolution views into polymers and multilayer organic films without damaging or obscuring their nanoscale features.

SEND US YOUR SAMPLES OR BOOK A  COVID SAFE DEMO TODAY!! 
Contact us for a demo
Request a quote now
Email us for more info
 
EXCITING ANNOUNCEMENTS: LATEST NEWS: WE ARE MOVING TO A NEW FACITIY!!
To serve you better with more space. From 1 November 2021, we will be moving to our new state-of-the-art facility to expand and meet the growing demand for high-quality analytical instruments, service and support solutions. READ MORE HERE

OUR YOUNG SCIENTIST ENCOURAGEMENT AWARD
Aimed to provide young scientists with financial assistance to further their education and attend scientific meetings and conferences. For all our previous winners,
CLICK HERE

COVID-19 Customer Response Plan
To help those that require analytical testing services adapted to the remote working environment.
READ MORE HERE 

Microcalorimetry – A versatile tool for the characterisation of biomolecular interactions

Newsletters
Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) are ideal techniques for the measurement of a wide range of binding interactions since they do not rely on the presence of chromophores or fluorophores, they don’t require labeling or immobilisation of the samples and there are no molecular weight limitations. ITC relies only on the detection of a heat effect upon binding. ITC and DSC enable scientists in academia and industry to better understand the conformational stability of their biomolecules and their binding to relevant interactants. 

In this webinar the benefits of PEAQ-ITC and PEAQ-DSC are discussed and how they help to address current bottlenecks associated with the study of interaction analysis and conformational stability. Among the most recognised challenges is the need to adequately address a broad range of binding affinities and to reliably interpret the binding data, complicated by the presence of inactive protein or inherent uncertainty in the concentration of the ligand. Experimental practicalities as well as how to obtain quality data will be covered.    

WATCH WEBINAR NOW    

This webinar is part of our ‘Ask an expert’ webinar series. These webinars are meant for students, researchers, and professors alike who want to sharpen their analytical methods, deepen their knowledge, or find out how to improve their data. Free to attend any of the classes. For full overview click here
 
Advances In Microcalorimetry – DSC Virtual Users meeting
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Learn how DSC advances life science and drug discovery around the globe. Updates to our data analysis software and tips and tricks for producing great data will be discussed.

Ask an expert – Zetasizer Frequently Asked Questions
WATCH NOW
In this event we cover frequently asked questions we receive from Zetasizer users on dynamic light scattering (DLS) and electrophoretic light scattering (ELS) measurements.

Innovative Assays for Immunotherapy Drug Discovery
WATCH NOW
In this webinar, we discuss the key players targeted in immunotherapy and how these cells and processes can be assessed in vitro. Approaches for selecting the most appropriate assay for your target of interest are covered.

Ask an expert – Top 5 tips for the Zetasizer
WATCH NOW
This webinar focuses on analysing data using a Zetasizer, what steps to take to ensure the data is meaningful, and what to do when there are issues present in the analysis.   
CONTACT US FOR MORE INFORMATION  
Contact us for a demo
Request a quote now
Email us for more info
 

Microcalorimetry – A versatile tool for the characterisation of biomolecular interactions

Newsletters
Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) are ideal techniques for the measurement of a wide range of binding interactions since they do not rely on the presence of chromophores or fluorophores, they don’t require labeling or immobilisation of the samples and there are no molecular weight limitations. ITC relies only on the detection of a heat effect upon binding. ITC and DSC enable scientists in academia and industry to better understand the conformational stability of their biomolecules and their binding to relevant interactants. 
In this webinar the benefits of PEAQ-ITC and PEAQ-DSC are discussed and how they help to address current bottlenecks associated with the study of interaction analysis and conformational stability. Among the most recognised challenges is the need to adequately address a broad range of binding affinities and to reliably interpret the binding data, complicated by the presence of inactive protein or inherent uncertainty in the concentration of the ligand. Experimental practicalities as well as how to obtain quality data will be covered.  

WATCH WEBINAR NOW  

This webinar is part of our ‘Ask an expert’ webinar series. These webinars are meant for students, researchers, and professors alike who want to sharpen their analytical methods, deepen their knowledge, or find out how to improve their data. Free to attend any of the classes. For full overview click here.
 
Advances In Microcalorimetry – DSC Virtual Users meeting
REGISTER NOW
Learn how DSC advances life science and drug discovery around the globe. Updates to our data analysis software and tips and tricks for producing great data will be discussed.

Ask an expert – Zetasizer Frequently Asked Questions
WATCH NOW
In this event we cover frequently asked questions we receive from Zetasizer users on dynamic light scattering (DLS) and electrophoretic light scattering (ELS) measurements.
 
Innovative Assays for Immunotherapy Drug Discovery
WATCH NOW
In this webinar, we discuss the key players targeted in immunotherapy and how these cells and processes can be assessed in vitro. Approaches for selecting the most appropriate assay for your target of interest are covered.
Ask an expert – Top 5 tips for the Zetasizer
WATCH NOW
This webinar focuses on analysing data using a Zetasizer, what steps to take to ensure the data is meaningful, and what to do when there are issues present in the analysis.   
CONTACT US FOR MORE INFORMATION  
Contact us for a demo
Request a quote now
Email us for more info

Exciting Announcement: ATA Scientific is moving to a new facility

Newsletters
Over 30 Years ago, ATA Scientific started its humble beginnings in what we affectionately called the Bundeena Bunker – located in the Royal National Park. As we grew in people and capability we moved to rented premises, including many years at the ANSTO Technology Park. We are now fortunate enough to move into our own building, at
 47 Cawarra Rd Caringbah, Sydney.

We will be moving to our new state-of-the-art facility to expand and meet the growing demand for high-quality analytical instruments, service and support solutions. The new building provides more space with the larger warehouse facility and additional offices for staff.

“We are very excited to expand to a new, larger facility. We are proud to maintain our service and support in Sydney,” Bryn McDonagh, Director of ATA Scientific, says. “The move will expand and greatly strengthen our capabilities to offer more support and training services for our customers as we continue to offer the latest analytical technologies from around the world”.

We have built our product range over the years and expanded our customer support capacity. Apart from our long-established Particle Characterisation instruments we now also have an exciting portfolio of Life Science products. This sector is likely to be a future powerhouse given the global focus on genetic medicines, vaccine development etc. We are now well positioned to enhance our ability to support and service the Life Scientific community. We will continue to invest in scientific endeavours such as our Young Scientists Encouragement Awards and conference sponsorships.

Our move is almost complete with the newly renovated, purpose-built service workshop, multiple conference and training rooms and a new office set up. This significant commitment is aimed to support partnerships across Australia and New Zealand. It will facilitate and expand multilevel support, from demonstrations and new product launches through to user training courses and educational seminars with guest speakers from our world leading suppliers. Stay tuned for more.  

We will keep you updated with the latest as we continue to move to our new office space! Contact us for a free lab tour and product demo today!!

  CONTACT US TODAY!!!  
We offer a broad range of products and services, focused in the areas of Particle, Material, Biomolecular Sciences and SEM/ Imaging. For a free consultation and quote, please get in touch.
Request training or a demo
Click here for sample testing
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DAY IN THE LIFE OF A RESEARCH STUDENT IN 60 SECONDS! 
If you are a young scientist you can enter our competition to win one of six $500 Encouragement Awards. This award is intended to provide you with financial assistance to attend a relevant science conference or to further your research or studies.   
CLICK HERE TO ENTER OUR AWARD  

Scaling non-viral gene delivery from preclinical stages to commercial manufacturing

Newsletters
Lipid-based genetic medicines have garnered recent attention with the expedited creation of COVID-19 vaccines and are transforming the way we approach other therapies. This recorded virtual symposium focuses on the challenges and successes associated with the scale up of genetic medicine production for clinical applications and microfluidic-based lipid nanoparticle manufacturing.
Talks include: Translation of RNA Nanomedicines from Design to Clinical; Development of an RNA-LNP Covid-19 Vaccine; mRNA-LNP scale-up for GMP Vaccine Production; Characterisation and Analysis of saRNA in Lipid Nanoparticles for Drug Delivery; Addressing Vaccine Demand With Rapid Deployment of mRNA Manufacturing; Aseptic Filling for mRNA-LNPs; RNA Vaccine Development to Phase I; Formulation and Process Development with PNI’s Contract Services.
Watch the presentation series – Click here    

Rethink T Cell Therapy with Lipid Nanoparticles.
Learn more about how the GenVoy-ILM T Cell Kit for mRNA can empower your research. Key learnings:
•    Review of current ex vivo gene delivery strategies for cell therapies
•    Introduction of GenVoy lipid nanoparticle delivery platform
•    Presentation of data in T cells comparing the GenVoy-ILM T Cell Kit for mRNA with electroporation
  Watch this presentation – Click here    

NanoMedU Early Pre-clinical RNA Vaccines Training course       
This course is aimed at providing pharmaceutical scientists with knowledge and confidence to start early preclinical development of RNA-LNP vaccines
 
Part I – Fundamentals
This interactive, live virtual classroom session covers fundamentals of RNA-LNP formulations, self-assembly and RNA vaccines. Learn the importance of the 4 Pillars of RNA vaccine development, advantages and disadvantages of unmodified, base-modified and self-amplifying vectors and more.

Part 2 – Practical
Live guided instruction for preparing RNA-LNPs for early preclinical development. A NanoAssemblr® Ignite™ and the purchase of a GenVoy-ILM training kit and payload is required, in addition to the course cost. Successful completion of Part I is required.  

Register now – NanoMedU training course – Limited places  

If you would like further information regarding these courses or anything else related to lipid, polymer or hybrid nanoparticle formulations carrying small molecules, peptides nucleic acids (and more), please contact Peter Davis, pdavis@atascientific.com.au, or call Peter directly on his mobile 0417 778 971. 
Request NanoAssemblr demo
Click here for sample testing
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AQS3Pro enables more sensitive & reproducible Protein Secondary Structure analysis using MMS

New products

When developing biotherapeutics, the ability to measure and characterise changes in the secondary structure of proteins is critical. Proteins in solution are prone to conformational change or instability as structural bonds are disrupted with thermal and chemical stresses in the local environment. Any structural change has the potential to compromise efficacy and trigger aggregation which can impact safety.

Conventional techniques such as FTIR and Circular Dichroism do not possess the adequate feature set for researchers to accurately assess changes in their proteins within the required conditions. The need for high sensitivity, a wide dynamic range, a simplified and automated workflow, and high repeatability is significant and, until now, has not been adequately provided.

The AQS3pro fills the gap for high sensitivity protein analysis with the novel IR technique called Microfluidic Modulation Spectroscopy (MMS).

The technique is purposely designed to directly address the limitations of current technologies and provide drift-free, background subtracted, high sensitivity measurements of the protein secondary structure. It is possible to measure protein similarity (fingerprinting), quantitation, higher order structure, protein stability, and aggregation through thermal and chemical denaturation methods using a walk-away automated platform.

The AQS3pro allows users to ‘see change’ in the secondary structure of proteins across a wide concentration range from 0.1mg/mL to over 200 mg/mL, and in the presence of excipients – the concentration range found across the full spectrum of drug development. Samples can be measured with minimal preparation and without dilution to generate data that is reliably representative of drug performance.

The AQS3™pro measures five key measurements—aggregation, quantitation, stability, similarity, structure to directly support protein characterisation throughout the biopharmaceutical development pipeline.

Contact us or Download the latest eBook for more information.

BOOK A PHENOM PHAROS FEG-SEM DEMO – LIMITED TIME IN AUSTRALIA

Newsletters
We invite you to use the NEW Phenom Pharos G2 Desktop Field Emission Gun – Scanning Electron Microscope (FEG-SEM), ready for use at our office in Sydney.

Phenom Pharos G2 combines all the capabilities of a floor-standing FEG-SEM in a tabletop system with the simplicity that Phenom desktop SEMs are known for. Fully integrated advanced detectors acquire high-quality images up to 2 million times in magnification, at 2.0 nm resolution and up to 20 kV. Users can also image soft, beam-sensitive or insulating samples at energy levels as low as 1 kV, obtaining high-resolution views into polymers and multilayer organic films without damaging or obscuring their nanoscale features.


BOOK A COVID SAFE DEMONSTRATION OR SAMPLE TESTING

Bookings are now available for a limited time only. Should you wish to use this instrument, simply contact us: Please send your samples, submit questions and comments to enquiries@atascientific.com.au or click below. 
CLICK HERE TO BOOK A DEMO TODAY

PHENOM PHAROS G2 FEG-SEM DELIVERS
*High-resolution imaging: 2.0 nm resolution
*A wide acceleration voltage range of 1-20 kV to image a wide range of samples.
*Integrated low / medium / high vacuum modes
*Images can be obtained in <30 seconds for high sample throughput.
*Ease-of-use with an intuitive user interface on a widescreen, 24-inch monitor 
*Quick installation (40% faster than the previous version) speeding time to results.
*Integrated power supply and robust parts designed to ensure reproducible data

DOWNLOAD THE DATASHEET

Sensitive materials require gentle conditions. With an acceleration voltage down to 1 kV, the Phenom Pharos G2 Desktop FEG-SEM images beam-sensitive samples without sample coating or other sample preparation. Left: pharmaceutical powder, imaged without damage at 1 kV. Right: the same sample imaged at 5 kV, with damage, illustrating the need for low-kV imaging.
Contact us for a demo
Request a quote now
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