EXODUS T-2800 Exosome Isolation For GMP Manufacturing

EXODUS T-2800 is a high efficiency exosome isolation system for large-scale GMP manufacturing. 

EXODUS T-2800 Exosome Isolation For GMP Manufacturing

EXODUS T-2800 is a high efficiency exosome isolation system for large-scale GMP manufacturing. 

Manufacturer EXODUS
Product Series EXODUS
Measurement principle Purification
Application Exosome isolation, Exosome Tracking
Sample type Plasma, urine, saliva, cerebrospinal fluid, tears, aqueous humor, synovial fluid, tissue, cell culture medium, bacterial culture medium, cell-derived vesicle, plant, etc
Isolation principleDual-Membrane Nanofiltration System
Processing volumes1-10 L
Processing speed1-2 L/h
Protein removal efficiency>99%
Temperature control2-8°C

Product Overview

EXODUS T-2800 is a large-scale, fully automatic label-free exosome isolation system that integrates sample pre-processing, exosome isolation, and collection.

This system is designed to support the industrial-scale, automated production of high-purity and high-yield exosomes, ensuring stability and compliance with Good Manufacturing Practices (GMP).

EXODUS is a highly efficient exosome isolation method that uses ultrasonic nano-filtration technology. A dual-membrane nanofiltration system integrates periodic negative pressure oscillation (NPO) and double-coupled ultrasonic harmonic oscillations (HO). Exosomes are precisely intercepted while free nucleic acid and protein impurities are removed from the sample, resulting in the extraction of ultra-pure exosomes.

EXODUS presents several advantages over conventional membrane separation methods enabling high-quality intact exosomes can be quickly and easily isolated with excellent yield and purity from various biofluids. It achieves clog-free ultra-fast purification of exosomes in high yield while eliminating contaminants including cell-free nucleic acids and lipoproteins which interfere with exosomal biomarker interpretation.

The EXODUS exosome isolation system outperforms other isolation techniques in speed, purity and yield offering a more efficient method to help drive new discoveries in biomedical research and translation. Isolated exosomes can be used for characterisation, screening of disease markers, exosome drug delivery, treatment, and regenerative medicine.

  • Demonstration video
  • BENEFITS
  • Applications

Demonstration video

BENEFITS

Three-in-one
Three functions are integrated into one instrument: sample pre-processing, isolation, and automatic recovery, all featuring simple and user-friendly operations.

Outstanding purity and yield
Protein removal efficiency >99%, with particle-to-protein ratio >5×108 particles/ug protein; exosome concentration >1×1011 particles/mL.

Reliable quality
The isolated exosomes are sterile and free from endotoxins, complying with established safety limits; it removes >99% of proteins from culture media, ensuring enhanced safety for downstream applications.

Stable and controllable
Fully automatic workflow that ensures batch-to-batch stability, full-process status monitoring, and intelligent handling.

Safe and compliant
A single-use approach: fully enclosed consumables that meet pharmacopeial standards, i.e., sterile and endotoxin-free products. The system and software
comply with GMP and 21 CFR part 11 requirements, respectively.

Applications

Publication list

NO. Title Journal IF
01 Exosome detection via the ultrafast-isolation system: EXODUS Nature Methods 47.990
02 Discovering the Secret of Diseases by Integrated Tear Exosomes Analysis via Rapid-isolation System: iTEARS ACS Nano 18.027
03 Robust Acute Pancreatitis Identification and Diagnosis: RAPIDx ACS Nano 18.027
04 Interaction network of extracellular vesicles building universal analysis via eye tears: iNEBULA Science Advances 14.980
05 The genetic source tracking of human urinary exosomes PNAS 12.779
06 Identification and detection of plasma extracellular vesicles-derived biomarkers for esophageal squamous cell carcinoma diagnosis  

Biosensors & Bioelectronics

 

12.545

07 Identification of circulating extracellular vesicle long RNAs as diagnostic biomarkers for patients with severe acute pancreatitis  

Clinical and Translational Medicine

 

10.600

08 Isolation of small extracellular vesicles from a drop of plasma via EXODUS and their fingerprint proteomics profiling by MALDI-TOF MS  

Biosensors & Bioelectronics:X

 

/

09 Audible Acoustic Wave Promotes EV Formation and Secretion from Adherent Cancer Cells via Mechanical Stimulation  

ACS Applied Materials & Interfaces

 

10.383

10 Quantitative metabolic analysis of plasma extracellular vesicles for the diagnosis of severe acute pancreatitis Journal of Nanobiotechnology 10.200
11 Lipidomic identification of urinary extracellular vesicles for non-alcoholic Journal of Nanobiotechnology 10.200
12 Metabolomic investigation of urinary extracellular vesicles for early detection and screening of lung cancer Journal of Nanobiotechnology 10.200
13 Metabolomic analysis of exosomal-markers in esophageal squamous cell carcinoma Nanoscale 8.307
14 Metabolic signatures of tear extracellular vesicles caused by herpes simplex keratitis The Ocular Surface 6.268
15 Isolation of Exosome Nanoparticles from Human Cerebrospinal Fluid for Proteomic Analysis ACS Applied Nano Materials 5.900
16 Human umbilical cord mesenchymal stem cells inhibit liver fibrosis via the microRNA-148a-5p/SLIT3 axis International Immunopharmacology 5.714
17 Efficient preparation of high-purity and intact mesenchymal stem cell–derived extracellular vesicles Analytical and Bioanalytical Chemistry 4.478
18 Liquid Biopsy Proteomics in Ophthalmology Journal of proteome research 5.370
19 Recent technical advances to study metabolomics of extracellular vesicles Microchemical Journal 5.304
20 Mesenchymal stem cell-derived extracellular vesicles for cell-free therapy of ocular diseases Extracellular Vesicles and Circulating Nucleic Acids /

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