Demonstration video

Benefits

Continuous size characterisation of nanoparticles during processing
• Inline Process Analytical Tool
• Non-invasive measurement
• Real-time process feedback
• Measurement of highly turbid materials
• High speed measurement
• Inline, online and offline operation
• For very small (<1mL) to large sample volumes

applications

Nano emulsions – with inline processing, the droplet size can be monitored in real time and thus the process variables can be modified accordingly to obtain the desirable droplet size.

• Measure emulsions created using high pressure homogenisation in food and pharma industries.
• Measure particle (droplet) size of a lipid nano-emulsion formulation with propofol (anesthetic for Covid-19 intensive care patients).
• Combine with other technologies like an NIR probe for particle size plus chemical composition in solution in real time.

Liposomes – Liposomes have a wide range of industrial applications; such as drug delivery vehicles in medicine, adjuvants in vaccination, signal enhancers in medical diagnostics etc. NanoFlowSizer allows:

• Inline size monitoring of liposomes at different scales (from microliter to liter), using a variety of modules.
• local behavior of the liposomes, such as interactions with the wall, can be tracked.
• Local dynamics and local size phenomena, e.g. depletion, and segregation, that standard DLS can not observe.

Vaccines, mRNA, protein molecules – Controlled and precise manufacturing of drug carrier systems (like the LNP-mRNA COVID-19 vaccines from Moderna and Pfizer) with a constant and narrow size distribution are required to achieve optimum clinical performance.

• Inline measurement of nanoparticle formulations can be used in either development laboratories, pilot plants or commercial operations.
• Production processes of vaccines get direct real time feedback about quality, purity and particle size every 10 seconds.
• Enables continuous nanomedicine manufacturing with the benefit of high quality, high efficiency and lower costs.

Nanoparticle synthesis – Nucleation and growth of particles during their synthesis can be monitored with real time feedback using a static or an inline setup. The NanoFlowSizer is capable of detecting changes in the backscattered intensity over time which are directly related to the concentration and size of nanoparticles in suspension. It can also monitor aggregation of particles.

• Silica, Iron, Titanium dioxide, Gold particles
• Polymers, Inks, Coatings