Demonstration video

Benefits

• Dynamic Light Scattering (DLS) measures particle and molecule size, from below 1 nm to 10 μm.
•  Electrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate.
• Sample-centric ZS Xplorer software enables flexible, guided use, and provides assistance as required.
• The deep-learning empowered Data Quality System assists users in understanding which of their size data might be poor, and why and also suggests how to improve results.
• Optical filter wheel offers a fluorescence filter and both vertical and horizontal polarisers for analytical flexibility.
• Adaptive Correlation produces reliable and repeatable data over twice as quickly, providing a truly representative view of the sample.
• NIBS (Non-Invasive Back-Scatter) technology maximises the dynamic range, providing the highest sensitivity for even the most concentrated samples.
• M3-PALS with Constant Current Mode measures electrophoretic mobility and zeta
  potential in high conductivity media.

Applications

• Bioscience and biopharmaceuticals: simple purity and stability screening can assist with formulation development. Time, temperature, pH and shear can all impact biological molecules and cause aggregation, which is detected by Zetasizer instruments.
• Pharmaceuticals and drug delivery: effective therapeutics must be delivered safely, with dispersion quality and stability being critical quality attributes.  Zetasizer systems can help speed up formulation development and final product development by providing insight earlier in the development pipeline.
• Paints, inks, and coatings: the stability of formulated nanoparticle suspensions is important, and both size and zeta potential help optimise product performance. Non-invasive back-scatter analysis can be used over a wide concentration range, with no/minimal dilution.
• Advanced Nanomaterials: Zetasizer instruments’ high sensitivity and low sample volume requirement can help guide in the early research and development phase of advanced materials design for materials like graphene, catalysts, and  nanotubes.
• Food and drink: appearance, stability and flavour emulsions are all influenced by some of the nanoscale properties light scattering can measure –  not only particle size but also particle charge, can influence the final consumable product.
• Consumer products ranging from detergents to cosmetics. Understanding of colloidal stability and control or adjustment of performance parameters helps guide product development.
• Academia: As an essential analytical instrument in many educational settings and academic research laboratories, tens of thousands of scientific publications attest to the widest range of suitable applications – and the particular ease-of-use and built-in reliability of Zetasizer systems have helped make them the favoured ‘go-to’ tools for rapid ensemble average size as well as zeta potential determination.

Accessories

Zetasizer Sample Assistant

Download brochure here

Zetasizer Sample Assistant is an automation option that enables users to generate more measurements of particle size, zeta potential, and particle concentration per day, while reducing the need for supervision.

MPT-3 Auto titrator

Designed to automate the measurement of size and zeta potential as a function of pH.

SV-10 Viscometer
Measures viscosity for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential. Useful for complex dispersants for which there are no available standard literature values for viscosity.

Disposable and reusable cells

A range of cells are available to optimise the measurement in terms of sample volume and concentration, including the new low volume disposable sizing cell kit, which offers the dual benefits of size measurements in as little as 3μL, and extension to the upper size range of DLS measurements.

*  New disposable folded capillary cell 

This new capillary enables contamination-free, high accuracy size, zeta potential and protein mobility measurements in as little as 20 μL of sample. The new capillary shape provides improved repeatability along with enhanced thermal performance.

*  Low volume disposable sizing cell (Zetasizer Ultra only)

A very low volume (minimum 3 μL) disposable sizing cuvette which extends the size measurement range for the Zetasizer without density-matching of the dispersant.

*   Universal ‘dip’ cell kit
A reusable solvent resistant cell for the measurement of zeta potential in aqueous and non-aqueous dispersants using polystyrene or glass cuvettes.

*  High concentration zeta potential cell kit
This high concentration cell enables measurement of the zeta potential of samples with little or no dilution required.

*  12 mm square glass cuvette

Compatible with both aqueous and non-aqueous solvents and dispersants, and is used for size measurements.

* Low-volume quartz cuvette

Holds between 12 μL and 45 μL of sample and is used for size measurements. It is compatible with both aqueous and non-aqueous solvents.

* 12 mm glass cell

Used for size and zeta potential measurements using the ‘dip’ cell, compatible with both aqueous and non-aqueous solvents and dispersants.

* 12 mm square polystyrene cuvette

For size measurements, and also for zeta potential measurements when used with the ‘dip’ cell. This cuvette is typically used for samples where cross-contamination might be an issue.

* Disposable micro-cuvette

Holds a maximum sample volume of 40 μL. Compatible with both aqueous and non-aqueous solvents and dispersants for size measurements.